Klaus Strebhardt Selected Research

BI 2536

12/2015	Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate Cancer.
1/2015	Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.
5/2014	Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis.

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Klaus Strebhardt Research Topics

Disease

58	Neoplasms (Cancer) 01/2022 - 01/2002
9	Breast Neoplasms (Breast Cancer) 12/2008 - 01/2002
8	Ovarian Neoplasms (Ovarian Cancer) 12/2021 - 05/2018
5	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2022 - 12/2002
4	Squamous Cell Carcinoma of Head and Neck 03/2008 - 11/2004
3	Carcinoma (Carcinomatosis) 01/2020 - 05/2002
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2019 - 03/2008
2	Genomic Instability 07/2021 - 01/2006
2	Chromosomal Instability (Chromosome Stability) 07/2021 - 01/2019
2	Neoplasm Metastasis (Metastasis) 01/2019 - 01/2016
2	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 08/2010
2	Carcinogenesis 01/2007 - 01/2005
1	Inflammation (Inflammations) 01/2021
1	Experimental Melanoma 10/2019
1	Lymphoma (Lymphomas) 10/2019
1	Ovarian Epithelial Carcinoma 01/2019
1	Neuroblastoma 01/2019
1	Anus Neoplasms (Anal Cancer) 01/2017
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 01/2017
1	Prostatic Neoplasms (Prostate Cancer) 12/2015
1	Choriocarcinoma 07/2015
1	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 07/2015
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2015
1	Leukemia 08/2012
1	Rectal Neoplasms (Rectal Cancer) 08/2010

Drug/Important Bio-Agent (IBA)

16	Polo-Like Kinase 1IBA 01/2022 - 08/2002
13	Phosphotransferases (Kinase)IBA 07/2021 - 05/2002
12	Pharmaceutical PreparationsIBA 01/2022 - 11/2005
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2002
9	Small Interfering RNA (siRNA)IBA 10/2019 - 06/2004
8	Caspase 8 (Caspase-8)IBA 01/2021 - 12/2010
7	Paclitaxel (Taxol)FDA LinkGeneric 07/2021 - 06/2006
5	Polo-like KinasesIBA 12/2021 - 01/2005
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2015
4	Adenosine Triphosphate (ATP)IBA 01/2021 - 12/2009
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2022 - 05/2008
3	Biological ProductsIBA 12/2021 - 01/2007
3	Taxoids (Taxanes)IBA 01/2021 - 06/2006
3	Messenger RNA (mRNA)IBA 01/2020 - 12/2002
3	BI 2536IBA 12/2015 - 05/2014
3	Cyclin B1IBA 07/2015 - 07/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2006 - 09/2002
2	PlatinumIBA 11/2021 - 01/2019
2	PAK inhibitor MRIA9IBA 07/2021 - 01/2021
2	taxaneIBA 01/2020 - 05/2018
2	LigandsIBA 01/2017 - 12/2009
2	Antineoplastic Agents (Antineoplastics)IBA 12/2015 - 06/2006
2	poloxinIBA 11/2015 - 10/2011
2	BI 6727IBA 01/2015 - 01/2015
2	Cisplatin (Platino)FDA LinkGeneric 03/2008 - 11/2005
2	Transcription Factors (Transcription Factor)IBA 07/2007 - 01/2007
2	Trastuzumab (Herceptin)FDA Link 10/2006 - 06/2006
2	Antisense OligonucleotidesIBA 06/2006 - 05/2002
2	Tetracycline (Achromycin)FDA LinkGeneric 01/2006 - 04/2005
2	ErbB Receptors (EGF Receptor)IBA 05/2005 - 11/2004
1	Death-Associated Protein KinasesIBA 01/2022
1	Topotecan (Hycamtin)FDA LinkGeneric 01/2022
1	4- (2,6- dichlorobenzoylamino)- 1H- pyrazole- 3- carboxylic acid piperidin-4-ylamideIBA 05/2021
1	onvansertibIBA 01/2021
1	SurvivinIBA 01/2021
1	Protein Kinases (Protein Kinase)IBA 01/2021
1	Vinca AlkaloidsIBA 01/2021
1	KinesinsIBA 01/2021
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2021
1	Inhibitor of Apoptosis ProteinsIBA 01/2021
1	Aurora KinasesIBA 01/2021
1	Antimitotic AgentsIBA 01/2020
1	Granzymes (Granzyme)IBA 10/2019
1	Carrier Proteins (Binding Protein)IBA 10/2019
1	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 10/2019
1	InterferonsIBA 10/2019
1	Anaplastic Lymphoma KinaseIBA 01/2019
1	Anaphase-Promoting Complex-CyclosomeIBA 01/2019
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018
1	RO 3306IBA 01/2018
1	CDC2 Protein Kinase (Protein p34cdc2)IBA 01/2018
1	dinaciclibIBA 01/2018
1	cobimetinibIBA 01/2018
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2016
1	Fluorouracil (Carac)FDA LinkGeneric 01/2016
1	CateninsIBA 12/2015
1	CyclinsIBA 07/2015
1	ArsenicIBA 01/2015
1	CarcinogensIBA 01/2015
1	Death Domain ReceptorsIBA 03/2014
1	Caspase 3 (Caspase-3)IBA 08/2010
1	CaspasesIBA 02/2010
1	Nucleic AcidsIBA 09/2009
1	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2008
1	Docetaxel (Taxotere)FDA Link 03/2008
1	Bortezomib (Velcade)FDA Link 03/2008

Therapy/Procedure

15	Therapeutics 01/2022 - 01/2002
4	Drug Therapy (Chemotherapy) 07/2021 - 02/2009
3	Chemoradiotherapy 11/2021 - 01/2016
2	Immunotherapy 10/2019 - 01/2017
2	Radiotherapy 01/2019 - 08/2010
1	Adjuvant Chemotherapy 01/2020
1	Brachytherapy 01/2019
1	Castration 12/2015
1	Combined Modality Therapy 08/2010